For years, he has been creating music for feature films (including Battle of Warsaw 1920, Ranczo Wilkowyje, Satan from the Seventh Grade, The Station, The Art of Loving. Story of Michalina Wislocka, Panic Attack), as well a TV series and theatre plays. He also composed about 30 symphonic and chamber pieces, which he often presents as a conductor. In April 2012 he won the competition for a remix of Beyoncé’s End of Time, and his remix was included on the artist's album 4: The Remix.
In August 2016, Radzimir Dębski hosted the JIMEK+ concert during the Solidarity of Arts Festival. The show attracted the audience of over eighteen thousand, who gathered on the Ołowianka Island in Gdańsk. In September 2016, he played a concert in Berlin's Konzerthaus, during which he led the Konzerthausorchester in symphonic arrangements of songs by German rapper MoTrip. The material was released by Deutsche Grammophon. In February 2018, he performed with a children's orchestra in Nairobi at the Safaricom International Jazz Festival, Africa's largest jazz festival. In the same month, he received the 2018 Eagle – the Polish Film Academy Award for his music for The Art of Loving. Story of Michalina Wisłocka (2017, dir. Maria Sadowska).
In April 2018, at the request of the POLIN Museum of the History of Polish Jews, he composed the Warsaw Ghetto Lament, which was first performed during the official celebrations on the 75th anniversary of the outbreak of the Warsaw Ghetto Uprising.